Videos

Extravasation of tumour cells

In cancer the blood-borne spread of tumor cells leads to the formation of secondary tumors. The extravasation of tumor cells is a prerequisite step during metastasis.

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Real-time Imaging of Vasculature

The ASET platform can be used to monitor in vivo physiological response in real time.

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Intravital Imaging of CAM Vasculature

The ASET Platform utilizes a unique animal model and imaging combination to create powerful images and movies of cellular processes. This video shows the movement of blood through the vasculature of the chorioallantoic membrane.

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Tumor Growth and Cell Migration

The ASET Platform can be used to monitor response to treatment at a macro and micro level.

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Targeting Therapeutics to Tumours

The ability to target a tumour cell to deliver chemotherapeutic agents spares healthy tissues. Here we show the specific targeting of a monoclonal antibody (anti-CD51) to breast cancer cells.

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Vascular Leak - No Treatment

The normal rate of vascular leak of a 70kDa dye particle from the CAM vasculature is seen above. Upper panel is raw data, lower panel is normalized to show dye particles that have leaked into the surrounding tissue from the blood vessels of the CAM.

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Vascular Leak Following VEGF Treatment

The enhanced rate of vascular leak of a 70kDa dye particle from the CAM vasculature after treatment with VEGF - a potent vascular permeability enhancing agent is shown above. Upper panel is raw data, lower panel is normalized to show dye particles that have leaked into the surrounding tissue from the blood vessels of the CAM.

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Vascular Leak Following LPS Treatment

This video shows the movement of two dyes out of blood vessels after LPS treatment. The red dye (158kDa) demonstrates vascular leak while the green dye (2M kDa) highlights areas of damaged vasculature (this is a control that should not leak from healthy vasculature). Left panels show raw data, middle panels show normal data - ie leak and rightmost panels: surface plots showing areas of increased leak.

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Tracking Tumour Cells In Vivo - Normal Movement

Tumour cells are constantly on the move. The ability to track and quantitate this movement is key to describing the efficacy of certain drugs to halt tumor cell migration (metastasis). In this video, tumour cells move about the tumour tissue unchecked.

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Tracking Tumour Cells In Vivo - Treatment Decreases Movement

Tumour cells are constantly on the move. The ability to track and quantitate this movement is key to describing the efficacy of certain drugs to halt tumor cell migration (metastasis). In this video, tumour cells movement has been diminished following treatment with a monoclonal-based therapy.

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